2023

The Lipid Metabolism as Target and Modulator of BOLD-100 Anticancer Activity: Crosstalk with Histone Acetylation
Baier, D., Mendrina, T., Schoenhacker-Alte, B., Pirker, C., Mohr, T., Rusz, M., Regner, B., Schaier, M., Sgarioto, N., Raynal, N. J. M., Nowikovsky, K., Schmidt, W. M., Heffeter, P., Meier-Menches, S. M., Koellensperger, G., Keppler, B. K. & Berger, W.
Advanced Science (2023) 10, 32, 2301939

Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs
Kastner, A., Mendrina, T., Babu, T., Karmakar, S., Poetsch, I., Berger, W., Keppler, B. K., Gibson, D., Heffeter, P. & Kowol, C. R.
Inorganic Chemistry Frontiers (2023) 11, 2, 534-548

Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes
Kastner, A., Schueffl, H., Yassemipour, P. A., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Angewandte Chemie - International Edition (2023) 62, 46, e202311468

Not the usual suspect - an unexpected organometallic product during the synthesis of cytotoxic platinum(II) complexes
Maier, T., Wutschitz, J., Gajic, N., Hejl, M., Cseh, K., Mai, S., Jakupec, M. A., Galanski, M. S. & Keppler, B. K.
Dalton Transactions (2023) 52, 44, 16326-16335

Cytotoxic Impact of Fluorinated Ligands in Equatorial Position of Trans-Configured Diam(m)inetetracarboxylatoplatinum(IV) Complexes
Lerchbammer-Kreith, Y., Hejl, M., Wenisch, D., Jakupec, M. A., Galanski, M. S. & Keppler, B. K.
Inorganics (2023) 11, 10, 411

Quaternary Ammonium Palmitoyl Glycol Chitosan (GCPQ) Loaded with Platinum-Based Anticancer Agents—A Novel Polymer Formulation for Anticancer Therapy
Lerchbammer-Kreith, Y., Hejl, M., Sommerfeld, N. S., Weng-Jiang, X., Odunze, U., Mellor, R. D., Workman, D. G., Jakupec, M. A., Schätzlein, A. G., Uchegbu, I. F., Galanski, M. S. & Keppler, B. K.
Pharmaceuticals (2023) 16, 7, 1027

Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
Solta, A., Boettiger, K., Kovacs, I., Lang, C., Megyesfalvi, Z., Ferk, F., Misík, M., Hoetzenecker, K., Aigner, C., Kowol, C. R., Knasmueller, S., Grusch, M., Szeitz, B., Rezeli, M., Dome, B. & Schelch, K.
Clinical Cancer Research (2023) 29, 22, 4644-4659

Influence of the Fatty Acid Metabolism on the Mode of Action of a Cisplatin(IV) Complex with Phenylbutyrate as Axial Ligands
Mendrina, T., Poetsch, I., Schueffl, H., Baier, D., Pirker, C., Ries, A., Keppler, B. K., Kowol, C. R., Gibson, D., Grusch, M., Berger, W. & Heffeter, P.
Pharmaceutics (2023) 15, 2, 677

Highly Cytotoxic Molybdenocenes with Strong Metabolic Effects Inhibit Tumour Growth in Mice
Fuchs, V., Cseh, K., Hejl, M., Vician, P., Neuditschko, B., Meier-Menches, S. M., Janker, L., Bileck, A., Gajic, N., Kronberger, J., Schaier, M., Neumayer, S., Koellensperger, G., Gerner, C., Berger, W., Jakupec, M. A., Malarek, M. S. & Keppler, B. K.
Chemistry: A European Journal (2023) 29, 4, e202202648

Methods to identify protein targets of metal-based drugs
Skos, L., Borutzki, Y., Gerner, C. & Meier-Menches, S. M.
Current opinion in chemical biology (2023) 73, 10225

Multi-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDs
Liu, X., Wenisch, D., Dahlke, P., Jordan, P. M., Jakupec, M. A., Kowol, C. R., Liebing, P., Werz, O., Keppler, B. K. & Weigand, W.
European Journal of Medicinal Chemistry (2023) 257, 115515

Beyond silver sulfadiazine: A dive into more than 50 years of research and development on metal complexes of sulfonamides in medicinal inorganic chemistry
Bormio Nunes, J. H., Hideki Nakahata, D., Corbi, P. P. & Ferraz de Paiva, R. E.
Coordination Chemistry Reviews (2023) 490, 215228

Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton
Borutzki, Y., Skos, L., Gerner, C. & Meier-Menches, S. M.
ChemBioChem (2023) 24, 17, e202300178

Human serum albumin as a copper source for anticancer thiosemicarbazones
Schaier, M., Falcone, E., Prstek, T., Vileno, B., Hager, S., Keppler, B. K., Heffeter, P., Koellensperger, G., Faller, P. & Kowol, C. R.
Metallomics (2023) 15, 8, mfad046

A novel EGFR inhibitor acts as potent tool for hypoxia-activated prodrug systems and exerts strong synergistic activity with VEGFR inhibition in vitro and in vivo
Caban, M., Koblmueller, B., Groza, D., Schueffl, H. H., Terenzi, A., Tolios, A., Mohr, T., Mathuber, M., Kryeziu, K., Jaunecker, C., Pirker, C., Keppler, B. K., Berger, W., Kowol, C. R. & Heffeter, P.
Cancer Letters (2023) 565, 216237

Anticancer Tungstenocenes with a Diverse Set of (O,O–), (O,S–) and (O,N–) Chelates—A Detailed Biological Study Using an Improved Evaluation via 3D Spheroid Models
Cseh, K., Berasaluce, I., Fuchs, V., Banc, A., Schweikert, A., Prado-Roller, A., Hejl, M., Wernitznig, D., Koellensperger, G., Jakupec, M. A., Kandioller, W., Malarek, M. S. & Keppler, B. K.
Pharmaceutics (2023) 15, 7, 1875

Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs
Kastner, A., Mendrina, T., Bachmann, F., Berger, W., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Inorganic Chemistry Frontiers (2023) 10, 14, 4126-4138

Degradable Bottlebrush Polypeptides and the Impact of their Architecture on Cell Uptake, Pharmacokinetics, and Biodistribution In Vivo
Strasser, P., Montsch, B., Weiss, S., Sami, H., Kugler, C., Hager, S., Schueffl, H., Mader, R., Brüggemann, O., Kowol, C. R., Ogris, M., Heffeter, P. & Teasdale, I.
Small (2023) 19, 22, 2300767

Aberrant DNA Methylation, Expression, and Occurrence of Transcript Variants of the ABC Transporter ABCA7 in Breast Cancer
Zappe, K., Kopic, A., Scheichel, A., Schier, A. K., Schmidt, L. E., Borutzki, Y., Miedl, H., Schreiber, M., Mendrina, T., Pirker, C., Pfeiler, G., Hacker, S., Haslik, W., Pils, D., Bileck, A., Gerner, C., Meier-Menches, S., Heffeter, P. & Cichna-Markl, M.
Cells (2023) 12, 11, 1462

Platinum(IV)-Loaded Degraded Glycol Chitosan as Efficient Platinum(IV) Drug Delivery Platform
Lerchbammer-Kreith, Y., Sommerfeld, N. S., Cseh, K., Weng-Jiang, X., Odunze, U., Schätzlein, A. G., Uchegbu, I. F., Galanski, M. S., Jakupec, M. A. & Keppler, B. K.
Pharmaceutics (2023) 15, 4, 1050

Multiparametric Tissue Characterization Utilizing the Cellular Metallome and Immuno-Mass Spectrometry Imaging
Schaier, M., Theiner, S., Baier, D., Braun, G., Berger, W. & Koellensperger, G.
JACS Au. (2023) 3, 2, 419-428

Synthesis, spectroscopic characterization, antibacterial activity and antiproliferative profile of a new silver(I) complex of 5-fluorocytosine
Pereira, G. D. M., Bormio Nunes, J. H., Cruz, Á. B., Pereira, D. H., Buglio, K. E., Ruiz, A. L. T. G., de Carvalho, J. E., Frajácomo, S. C. L., Lustri, W. R., Bergamini, F. R. G. & Corbi, P. P.
Journal of Fluorine Chemistry (2023) 266, 110096

Multi-omics empowered deep phenotyping of ulcerative colitis identifies biomarker signatures reporting functional remission states
Janker, L., Schuster, D., Bortel, P., Hagn, G., Meier-Menches, S. M., Mohr, T., Mader, J. C., Slany, A., Bileck, A., Brunmair, J., Madl, C., Unger, L., Hennlich, B., Weitmayr, B., Del Favero, G., Pils, D., Pukrop, T., Pfisterer, N., Feichtenschlager, T. & Gerner, C.
Journal of Crohn's & Colitis (2023) jjad052

Semiquantitative Analysis for High-Speed Mapping Applications of Biological Samples Using LA-ICP-TOFMS
Metarapi, D., Schweikert, A., Jerše, A., Schaier, M., van Elteren, J. T., Koellensperger, G., Theiner, S. & Šala, M.
Analytical Chemistry (2023) 95, 19, 7804-7812

Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes—A More Selective Anticancer Treatment?
Lerchbammer-Kreith, Y., Hejl, M., Vician, P., Jakupec, M. A., Berger, W., Galanski, M. S. & Keppler, B. K.
Pharmaceutics (2023) 15, 5, 1515

2022

The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation
Baier, D., Schönhacker-Alte, B., Rusz, M., Pirker, C., Mohr, T., Mendrina, T., Kirchhofer, D., Meier-Menches, S. M., Hohenwallner, K., Schaier, M., Rampler, E., Koellensperger, G., Heffeter, P., Keppler, B. & Berger, W.
Pharmaceutics (2022) 14, 2, 238

Trabectedin Is Active against Two Novel, Patient-Derived Solitary Fibrous Pleural Tumor Cell Lines and Synergizes with Ponatinib
Ghanim, B., Baier, D., Pirker, C., Muellauer, L., Sinn, K., Lang, G., Hoetzenecker, K. & Berger, W.
Cancers (2022) 14, 22, 5602

Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance
Posa, V., Stefanelli, A., Nunes, J. H. B., Hager, S., Mathuber, M., May, N., Berger, W., Keppler, B. K., Kowol, C. R., Enyedy, E. A. & Heffeter, P.
Cancers (2022) 14, 18, 4455

Copper-Catalyzed Glutathione Oxidation is Accelerated by the Anticancer Thiosemicarbazone Dp44mT and Further Boosted at Lower pH
Falcone, E., Ritacca, A. G., Hager, S., Schueffl, H., Vileno, B., El Khoury, Y., Hellwig, P., Kowol, C. R., Heffeter, P., Sicilia, E. & Faller, P.
Journal of the American Chemical Society (2022) 144, 32, 14758-14768

The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity
Pósa, V., Hajdu, B., Tóth, G., Dömötor, O., Kowol, C. R., Keppler, B. K., Spengler, G., Gyurcsik, B. & Enyedy, E. A.
Journal of Inorganic Biochemistry (2022) 231, 111786

A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance
Fronik, P., Gutmann, M., Vician, P., Stojanovic, M., Kastner, A., Heffeter, P., Pirker, C., Keppler, B. K., Berger, W. & Kowol, C. R.
Communications Chemistry (2022) 5, 1, 46

Systematic Study on the Cytotoxic Potency of Commonly Used Dimeric Metal Precursors in Human Cancer Cell Lines
Geisler, H., Harringer, S., Wenisch, D., Urban, R., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
ChemistryOpen (2022), e202200019

Arene Variation of Highly Cytotoxic Tridentate Naphthoquinone-Based Ruthenium(II) Complexes and In-Depth In Vitro Studies
Cseh, K., Geisler, H., Stanojkovska, K., Westermayr, J., Brunmayr, P., Wenisch, D., Gajic, N., Hejl, M., Schaier, M., Koellensperger, G., Jakupec, M. A. A., Marquetand, P. & Kandioller, W.
Pharmaceutics (2022) 14, 11, 2466

An Anticancer Rhenium Tricarbonyl Targets Fe-S Cluster Biogenesis in Ovarian Cancer Cells
Neuditschko, B., King, A. P., Huang, Z., Janker, L., Bileck, A., Borutzki, Y., Marker, S. C., Gerner, C., Wilson, J. J. & Meier-Menches, S. M.
Angewandte Chemie (International Edition) (2022) 61, 43, e202209136

Novel oxaliplatin(IV) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs
Liu, X., Wenisch, D., Barth, M-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Gibson, D., Keppler, B. K. & Weigand, W.
Dalton Transactions (2022) 51, 44, 16824-16835

Oxoplatin-Based Pt(IV) Lipoate Complexes and Their Biological Activity
Liu, X., Barth, M-C., Cseh, K., Kowol, C. R., Jakupec, M. A., Keppler, B. K., Gibson, D. & Weigand, W.
Chemistry & Biodiversity (2022) 19, 10, e202200695

2021

Water-soluble trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes with bisphosphonate functionalized ligands as anticancer organometallics
Riedl, C. A., Rosner, A., Harringer, S., Salomon, P., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Journal of Inorganic Biochemistry (2021), 225, 111618

Landomycins as glutathione-depleting agents and natural fluorescent probes for cellular Michael adduct-dependent quinone metabolism
Terenzi, A., La Franca, M., van Schoonhoven, S., Panchuk, R., Martinez, A., Heffeter, P., Gober, R., Pirker, C., Vician, P., Kowol, C. R., Stoika, R., Salassa, L., Rohr, J. & Berger, W.
Communications Chemistry (2021) 4, 1, 162

Current and emerging mass spectrometry methods for the preclinical development of metal-based drugs: a critical appraisal
Jarosz, M., Keppler, B. K. & Timerbaev, A. R.
Analytical and Bioanalytical Chemistry (2021)

KP772 overcomes multiple drug resistance in malignant lymphoma and leukemia cells in vitro by inducing Bcl-2-independent apoptosis and upregulation of Harakiri
Kater, L., Kater, B., Jakupec, M. A., Keppler, B. K. & Prokop, A.
Journal of Biological Inorganic Chemistry (2021) 26, 897-907

Liposomal formulations of anticancer copper(ii) thiosemicarbazone complexes
Mathuber, M., Hager, S., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Dalton Transactions (2021) 50, 16053-16066

Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake in vivo
Schueffl, H., Theiner, S., Hermann, G., Mayr, J., Fronik, P., Groza, D., van Schonhooven, S., Galvez, L., Sommerfeld, N. S., Schintlmeister, A., Reipert, S., Wagner, M., Mader, R. M., Koellensperger, G., Keppler, B. K., Berger, W., Kowol, C. R., Legin, A. & Heffeter, P.
Chemical Science (2021) 38, 12587-12599

Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands
Fronik, P., Poetsch, I., Kastner, A., Mendrina, T., Hager, S., Hohenwallner, K., Schueffl, H., Herndler-Brandstetter, D., Koellensperger, G., Rampler, E., Kopecka, J., Riganti, C., Berger, W., Keppler, B. K., Heffeter, P. & Kowol, C. R.
Journal of Medicinal Chemistry (2021) 64, 16, 12132-12151

Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids
Petrasheuskaya, T. V., Wernitznig, D., Kiss, M. A., May, N. V., Wenisch, D., Keppler, B. K., Frank, E. & Enyedy, E. A.
Journal of Biological Inorganic Chemistry (2021) 26, 775-791

Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer
Herrmann, H. A., Rusz, M., Baier, D., Jakupec, M. A., Keppler, B. K., Berger, W., Koellensperger, G. & Zanghellini, J.
Cancers (2021) 13, 16, 4130

Morpho-metabotyping the oxidative stress response
Rusz, M., Del Favero, G., El Abiead, Y., Gerner, C., Keppler, B. K., Jakupec, M. A. & Koellensperger, G.
Scientific Reports (2021) 11, 1, 15471

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies
Geisler, H., Westermayr, J., Cseh, K., Wenisch, D., Fuchs, V., Harringer, S., Plutzar, S., Gajic, N., Hejl, M., Jakupec, M. A., Marquetand, P. & Kandioller, W.
Inorganic Chemistry (2021) 60, 13, 9805-9819

Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity
Enyedy, E. A., Petrasheuskaya, T., Kiss, M. A., Wernitznig, D., Wenisch, D., Keppler, B. K., Spengler, G., May, N., Frank, E. & Domotor, O.
Journal of Inorganic Biochemistry (2021) 220, 111468

Multifunctional Pt(iv) prodrug candidates featuring the carboplatin core and deferoxamine
Harringer, S., Hejl, M., Enyedy, E. A., Jakupec, M. A., Galanski, M. S., Keppler, B. K., Dyson, P. J. & Varbanov, H. P.
Dalton Transactions (2021) 50, 8167-8178

Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS
Schweikert, A., Theiner, S., Wernitznig, D., Schoeberl, A., Schaier, M., Neumayer, S., Keppler, B. K. & Koellensperger, G.
Analytical and Bioanalytical Chemistry (2021)

Red Blood Cell Stiffness and Adhesion Are Species-Specific Properties Strongly Affected by Temperature and Medium Changes in Single Cell Force Spectroscopy
Baier, D., Mueller, T., Mohr, T. & Windberger, U.
Molecules (2021) 26, 9, 2771

Mass spectrometry techniques for imaging and detection of metallodrugs
Theiner, S., Schoeberl, A., Schweikert, A., Keppler, B. K. & Koellensperger, G.
Current opinion in chemical biology (2021) 61, 123-134

Development of a cobalt(iii)-based ponatinib prodrug system
Mathuber, M., Gutmann, M., La Franca, M., Vician, P., Laemmerer, A., Moser, P., Keppler, B. K., Berger, W. & Kowol, C. R.
Inorganic Chemistry Frontiers (2021)

Doubly derivatized poly(lactide)-albumin nanoparticles as blood vessel-targeted transport device for magnetic resonance imaging (MRI)
Pashkunova-Martic, I., Kremser, C., Talasz, H., Mistlberger, K., Bechter-Hugl, B., Pfaller, K., Baurecht, D., Debbage, P., Jaschke, W., Helbich, T. H. & Keppler, B.
Journal of Nanoparticle Research (2021) 23, 2, 51

Interaction with Ribosomal Proteins Accompanies Stress Induction of the Anticancer Metallodrug BOLD-100/KP1339 in the Endoplasmic Reticulum
Neuditschko, B., Legin, A. A., Baier, D., Schintlmeister, A., Reipert, S., Wagner, M., Keppler, B. K., Berger, W., Meier-Menches, S. M. & Gerner, C.
Angewandte Chemie (International Edition) (2021) 60, 10, 5063-5068

2020

Improving the Stability of Maleimide-Thiol Conjugation for Drug Targeting
Lahnsteiner, M., Kastner, A., Mayr, J., Roller, A., Keppler, B. K. & Kowol, C. R.
Chemistry: A European Journal (2020)

Nano-scale imaging of dual stable isotope labeled oxaliplatin in human colon cancer cells reveals the nucleolus as a putative node for therapeutic effect
Legin, A., Schintlmeister, A., Sommerfeld, N., Eckhard, M., Theiner, S., Reipert, S., Strohhofer, D., Jakupec, M., Galanski, M., Wagner, M. & Keppler, B.
Nanoscale Advances (2020) 3, 1, 249-262

Introducing N-, P-, and S-donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes
Harringer, S., Wernitznig, D., Gajic, N., Diridl, A., Wenisch, D., Hejl, M., Jakupec, M. A., Theiner, S., Koellensperger, G., Kandioller, W. & Keppler, B. K.
Dalton Transactions (2020) 49, 44, 15693-15711

Plecstatin-1 induces an immunogenic cell death signature in colorectal tumour spheroids
Wernitznig, D., Meier-Menches, S. M., Cseh, K., Theiner, S., Wenisch, D., Schweikert, A., Jakupec, M. A., Koellensperger, G., Wernitznig, A., Sommergruber, W. & Keppler, B. K.
Metallomics (2020) 12, 12, 2121-2133

First insights into the novel class of organometallic compounds bearing a bidentate selenopyridone coordination motif: Synthesis, characterization, stability and biological investigations
Harringer, S., Matzinger, M., Gajic, N., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Inorganica Chimica Acta (2020) 513, 119919

Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs
Mathuber, M., Schueffl, H., Dömötör, O., Karnthaler, C., Enyedy, É. A., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Inorganic Chemistry (2020)

Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation
Enyedy, É. A., May, N. V., Pape, V. F. S., Heffeter, P., Szakács, G., Keppler, B. K. & Kowol, C. R.
Dalton Transactions (2020) 49, 46, 16887-16902

High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones
Hager, S., Pape, V. F. S., Posa, V., Montsch, B., Uhlik, L., Szakacs, G., Toth, S., Jabronka, N., Keppler, B. K., Kowol, C. R., Enyedy, E. A. & Heffeter, P.
Antioxidants and Redox Signaling (2020), 395-414

Development and biological investigations of hypoxia-sensitive prodrugs of the tyrosine kinase inhibitor crizotinib
Bielec, B., Schueffl, H., Terenzi, A., Berger, W., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Bioorganic Chemistry (2020) 99, 103778

Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior
Harringer, S., Happl, B., Ozenil, M., Kast, C., Hejl, M., Wernitznig, D., Legin, A. A., Schweikert, A., Gajic, N., Roller, A., Koellensperger, G., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Chemistry: A European Journal (2020) 26, 24, 5419-5433

Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles
Mokesch, S., Cseh, K., Geisler, H., Hejl, M., Klose, M. H. M., Roller, A., Meier-Menches, S. M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Frontiers in Chemistry (2020) 8, 209

Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase II alpha inhibitors
Legina, M. S., Nogueira, J. J., Kandioller, W., Jakupec, M. A., Gonzalez, L. & Keppler, B. K.
Journal of Biological Inorganic Chemistry (2020), 451-465

Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib
Englinger, B., Laemmerer, A., Moser, P., Kallus, S., Roehrl, C., Pirker, C., Baier, D., Mohr, T., Niederstaetter, L., Meier-Menches, S. M., Gerner, C., Gabler, L., Gojo, J., Timelthaler, G., Senkiv, J., Jaeger, W., Kowol, C. R., Heffeter, P. & Berger, W.
International Journal of Cancer (2020)

Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib
Bielec, B., Poetsch, I., Ahmed, E., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Molecules (2020) 25, 5

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behavior
Geisler, H., Wernitznig, D., Hejl, M., Gajic, N., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (2020) 49, 5, 1393-1397

Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations
Meszaros, J. P., Geisler, H., Poljarevic, J. M., Roller, A., Legina, M. S., Hejl, M., Jakupec, M. A., Keppler, B. K., Kandioller, W. & Enyedy, E. A.
Journal of Organometallic Chemistry (2020) 907, 121070

2019

Ruthenium arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition
Hager, L. A., Mokesch, S., Kieler, C., Alonso-de Castro, S., Baier, D., Roller, A., Kandioller, W., Keppler, B. K., Berger, W., Salassa, L. & Terenzi, A.
Dalton Transactions (2019) 48, 32, 12040-12049

Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group
Mokesch, S., Schwarz, D., Hejl, M., Klose, M. H. M., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Molecules (2019) 24, 13, 2373

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal Pt-II Metallacycle
Domarco, O., Kieler, C., Pirker, C., Dinhof, C., Englinger, B., Reisecker, J. M., Timelthaler, G., Garcia, M. D., Peinador, C., Keppler, B. K., Berger, W. & Terenzi, A.
Angewandte Chemie (International Edition) (2019) 58, 24, 8007-8012

First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro
Wernitznig, D., Kiakos, K., Del Favero, G., Harrer, N., Machat, H., Osswald, A., Jakupec, M. A., Wernitznig, A., Sommergruber, W. & Keppler, B. K.
Metallomics (2019) 11, 6, 1044-1048

Heart-cut 2DSEC-RP-LC-ICP-MS as a screening tool in metal-based anticancer research
Galvez, L., Rusz, M., Jakupec, M. A. & Koellensperger, G.
Journal of Analytical Atomic Spectrometry (2019) 34, 6, 1279-1286

Synthesis, characterization, lipophilicity and cytotoxic properties of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes
Hizal, S., Hejl, M., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Inorganica Chimica Acta (2019) 491, 76-83

A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt-IV Complexes under Physiological Conditions
Kastner, A., Poetsch, I., Mayr, J., Burda, J. V., Roller, A., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Angewandte Chemie (International Edition) (2019) 58, 22, 7464-7469

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis
Groza, D., Gehrig, S., Dinhof, C., Holcman, M., Pirker, C., Schueffl, H., Ogris, M., Lubitz, W., Keppler, B., Pashkunova-Martic, I., Kowol, C., Berger, W. & Heffeter, P.
European Journal of Cancer (2019) 110, S1, S23-S24

Synthesis, Characterization, Cytotoxicity, and Time-Dependent NMR Spectroscopic Studies of (SP-4-3)-Oxalato[(1R,2R,4R/1S,2S,4S)-(4-trifluoromethyl-cyclohexane-1,2-diamine)]platinum(II)
Hizal, S., Hejl, M., Jungmann, C., Jakupec, M. A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2019) 6, 856-864

Metal Drugs and the Anticancer Immune Response
Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K. & Berger, W.
Chemical Reviews (2019) 119, 2, 1519-1624

Synthesis, characterization, cytotoxic activity, and ¹⁹F NMR spectroscopic investigations of (OC-6-33)-diacetato(ethane-1,2-diamine)bis(3,3,3-trifluoropropanoato)platinum(IV) and its platinum(II) counterpart
Hoefer, D., Cseh, K., Hejl, M., Roller, A., Jakupec, M. A., Galanski, M. & Keppler, B. K.,
Inorganica Chimica Acta (2019) 490, 190-199

Keggin-type polyoxotungstates as mushroom tyrosinase inhibitors - A speciation study
Breibeck, J., Gumerova, N. I., Boesen, B. B., Galanski, M. & Rompel, A.
Scientific Reports (2019) 9, 12, 5183

Synthesis, Characterization, Cytotoxicity, and Time-Dependent NMR Spectroscopic Studies of (SP-4-3)-Oxalato[(1R,2R,4R/1S,2S,4S)-(4-trifluoromethyl-cyclohexane-1,2-diamine)]platinum(II)
Hizal, S., Hejl, M., Jungmann, C., Jakupec, M. A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2019) 6, 856-864

Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes
Kallus, S., Uhlik, L., van Schoonhoven, S., Pelivan, K., Berger, W., Enyedy, E. A., Hofmann, T., Heffeter, P., Kowol, C. R. & Keppler, B. K.
Journal of Inorganic Biochemistry (2019) 190, 85-97

Synthesis, Characterization and in vitro Studies of a Cathepsin B-Cleavable Prodrug of the VEGFR Inhibitor Sunitinib
Karnthaler-Benbakka, C., Koblmueller, B., Mathuber, M., Holste, K., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K.
Chemistry & Biodiversity (2019) 16, 1, 1800520

2018

Lysosomal Sequestration Impairs the Activity of the Preclinical FGFR Inhibitor PD173074
Englinger, B., Kallus, S., Senkiv, J., Laemmerer, A., Moser, P., Gabler, L., Groza, D., Kowol, C. R., Heffeter, P., Grusch, M. & Berger, W.
Fuel Cells (2018) 7, 12, 259

Biological activity of Pt-IV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis
Alonso-de Castro, S., Terenzi, A., Hager, S., Englinger, B., Faraone, A., Calvo Martinez, J., Galanski, M., Keppler, B. K., Berger, W. & Salassa, L.
Scientific Reports (2018) 8, 17198

New Variations on the Theme of Gold(III) C boolean AND N boolean AND N Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization
Carboni, S., Zucca, A., Stoccoro, S., Maiore, L., Arca, M., Ortu, F., Artner, C., Keppler, B. K., Meier-Menches, S. M., Casini, A. & Cinellu, M. A.
Inorganic Chemistry (2018) 57, 23, 14852-14865

Biological activity of Pt-IV prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis
Alonso-de Castro, S., Terenzi, A., Hager, S., Englinger, B., Faraone, A., Calvo Martinez, J., Galanski, M., Keppler, B. K., Berger, W. & Salassa, L.
Scientific Reports (2018) 8, 17198

The Impact of Leaving Group Variation on the Anticancer Activity of Molybdenocenes
Kandioller, W., Reikersdorfer, M., Theiner, S., Roller, A., Hejl, M., Jakupec, M. A., Malarek, M. S. & Keppler, B. K.
Organometallics (2018) 37, 21, 3909-3916

Critical assessment of different methods for quantitative measurement of metallodrug-protein associations
Galvez, L., Theiner, S., Grabarics, M., Kowol, C. R., Keppler, B. K., Hann, S. & Koellensperger, G.,
Analytical and Bioanalytical Chemistry (2018) 410, 27, 7211-7220

Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index
Kallus, S., Englinger, B., Senkiv, J., Laemmerer, A., Heffeter, P., Berger, W., Kowol, C. R. & Keppler, B. K.
Nanomedicine: Nanotechnology Biology and Medicine (2018) 14, 8, 2632-2643

The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition
Hager, S., Korbula, K., Bielec, B., Grusch, M., Pirker, C., Schosserer, M., Liendl, L., Lang, M., Grillari, J., Nowikoysky, K., Pape, V. F. S., Mohr, T., Szakacs, G., Keppler, B. K., Berger, W., Kowol, C. R. & Heffeter, P.
Cell Death & Disease (2018) 9, 1052

Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS
Klose, M. H. M., Schöberl, A., Heffeter, P., Berger, W., Hartinger, C. G., Koellensperger, G., Meier-Menches, S. M. & Keppler, B. K.
Monatshefte für Chemie (2018) 149, 10, 1719-1726

Understanding the interactions of diruthenium anticancer agents with amino acids
Nazarov, A. A., Mendoza Parra Ferri, M. G., Hanif, M., Keppler, B. K., Dyson, P. J. & Hartinger, C. G.
Journal of Biological Inorganic Chemistry (2018) 23, 7, 1159-1164

Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction
Streciwilk, W., Terenzi, A., Cheng, X., Hager, L., Dabiri, Y., Prochnow, P., Bandow, J. E., Woelfl, S., Keppler, B. K. & Ott, I.
European Journal of Medicinal Chemistry (2018), 156, 148-161

NO Releasing and Anticancer Properties of Octahedral Ruthenium-Nitrosyl Complexes with Equatorial 1H-Indazole Ligands
Orlowska, E., Babak, M. V., Domotor, O., Enyedy, E. A., Rapta, P., Zalibera, M., Bucinsky, L., Malcek, M., Govind, C., Karunakaran, V., Farid, Y. C. S., McDonnell, T. E., Luneau, D., Schaniel, D., Ang, W. H. & Arion, V. B.
Inorganic Chemistry (2018) 57, 17, 10702-10717

Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands
Streciwilk, W., Terenzi, A., Lo Nardo, F., Prochnow, P., Bandow, J. E., Keppler, B. K. & Ott, I.
European Journal of Inorganic Chemistry (2018) 26, 3104-3112

Uranium concentrations in sediment pore waters of Lake Neusiedl, Austria
Krachler, R., Krachler, R., Guelce, F., Keppler, B. K. & Wallner, G.
Science of the Total Environment (2018) 633, 981-988

Comparative studies on the human serum albumin binding of the clinically approved EGFR inhibitors gefitinib, erlotinib, afatinib, osimertinib and the investigational inhibitor KP2187
Domotor, O., Pelivan, K., Borics, A., Keppler, B. K., Kowol, C. R. & Enyedy, E. A.
Journal of Pharmaceutical and Biomedical Analysis (2018) 154, 321-331

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)
Frensemeier, L. M., Mayr, J., Koellensperger, G., Keppler, B. K., Kowol, C. R. & Karst, U.
The Analyst (2018) 143, 9, 1997-2001

Design, synthesis, nuclear localization, and biological activity of a fluorescent duocarmycin analog, HxTfA
Kiakos, K., Englinger, B., Yanow, S. K., Wernitznig, D., Jakupec, M. A., Berger, W., Keppler, B. K., Hartley, J. A., Lee, M. & Patil, P. C.
Bioorganic & Medicinal Chemistry Letters (2018) 28, 8, 1342-1347

The impact of whole human blood on the kinetic inertness of platinum(IV) prodrugs - an HPLC-ICP-MS study
Theiner, S., Grabarics, M., Galvez, L., Varbanov, H. P., Sommerfeld, N. S., Galanski, M., Keppler, B. K. & Koellensperger
Dalton Transactions (Print Edition) (2018) 47, 15, 5252-5258

N- and S-donor leaving groups in triazole-based ruthena(II) cycles: potent anticancer activity, selective activation, and mode of action studies
Riedl, C. A., Hejl, M., Klose, M. H. M., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (Print Edition) (2018) 47, 13, 4625-4638

Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action
Babak, M. V., Pfaffeneder-Kmen, M., Meier-Menches, S. M., Legina, M. S., Theiner, S., Licona, C., Orvain, C., Hejl, M., Hanif, M., Jakupec, M. A., Keppler, B. K., Gaiddon, C. & Hartinger, C. G.
Inorganic Chemistry (2018) 57, 5, 2851-2864

A comparative study of alpha-N-pyridyl thiosemicarbazones: Spectroscopic properties, solution stability and copper(II) complexation
Domotor, O., May, N. V., Pelivan, K., Kiss, T., Keppler, B. K., Kowol, C. R. & Enyedy, E. A.
Inorganica Chimica Acta (2018) 472, 264-275

Bioimaging of isosteric osmium and ruthenium anticancer agents by LA-ICP-MS
Klose, M. H. M., Theiner, S., Kornauth, C., Meier-Menches, S. M., Heffeter, P., Berger, W., Koellensperger, G. & Keppler, B. K.
Metallomics (2018) 10, 3, 388-396

Complexes of pyridoxal thiosemicarbazones formed with vanadium(IV/V) and copper(II): Solution equilibrium and structure
Jakusch, T., Kozma, K., Enyedy, E. A., May, N. V., Roller, A., Kowol, C. R., Keppler, B. K. & Kiss, T.
Inorganica Chimica Acta (2018) 472, 243-253

Comparison of metabolic pathways of different alpha-N-heterocyclic thiosemicarbazones
Pelivan, K., Frensemeier, L. M., Karst, U., Koellensperger, G., Heffeter, P., Keppler, B. K. & Kowol, C. R.
Analytical and Bioanalytical Chemistry (2018) 410, 9, 2343-2361

Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development
Heffeter, P., Pape, V. F. S., Enyedy, E. A., Keppler, B. K., Szakacs, G. & Kowol, C. R.
Antioxidants and Redox Signaling (2018)

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development
Meier-Menches, S. M., Gerner, C., Berger, W., Hartinger, C. G. & Keppler, B. K.
Chemical Society Reviews (2018) 47, 3, 909-928

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis
Groza, D., Gehrig, S., Kudela, P., Holcmann, M., Pirker, C., Dinhof, C., Schueffl, H. H., Sramko, M., Hoebart, J., Alioglu, F., Grusch, M., Ogris, M., Lubitz, W., Keppler, B. K., Pashkunova-Martic, I., Kowol, C. R., Sibilia, M., Berger, W. & Heffeter, P.
OncoImmunology (2018) 7, 5, 1424676

Studies of KP46 and KP1019 and the Hydrolysis Product of KP1019 in Lipiodol Emulsions: Preparation and Initial Characterizations as Potential Theragnostic Agents
Pashkunova-Martic, I., Cebrian Losantos, B., Kandler, N. & Keppler, B. Current Drug Delivery (2018) 15, 1, 134 - 142

On the Tautomerism of N-Substituted Pyrazolones: 1,2-Dihydro-3H-pyrazol-3-ones versus 1H-Pyrazol-3-ols
Arbaciauskiene, E., Krikstolaityte, S., Mitruleviciene, A., Bieliauskas, A., Martynaitis, V., Bechmann, M., Roller, A., Sackus, A. & Holzer, W.
Molecules (2018) 23, 1, 129

2017

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis
Schoenhacker-Alte, B., Mohr, T., Pirker, C., Kryeziu, K., Kuhn, P-S., Buck, A., Hofmann, T., Gerner, C., Hermann, G., Koellensperger, G., Keppler, B. K., Berger, W. & Heffeter, P.
Cancer Letters (2017) 404, 79-88

Synthesis and in vivo anticancer evaluation of poly(organo) phosphazene-based metallodrug conjugates
Hackl, C. M., Schoenhacker-Alte, B., Klose, M. H. M., Henke, H., Legina, M. S., Jakupec, M. A., Berger, W., Keppler, B. K., Brueggemann, O., Teasdale, I., Heffeter, P. & Kandioller, W.
Dalton Transactions (Print Edition) (2017) 46, 36, 12114-12124

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
Englinger, B., Kallus, S., Senkiv, J., Heilos, D., Gabler, L., Van Schoonhoven, S., Terenzi, A., Moser, P., Pirker, C., Timelthaler, G., Jaeger, W., Kowol, C. R., Heffeter, P., Grusch, M. & Berger, W.
Journal of Experimental and Clinical Cancer Research  (2017) 36, 122

Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS
Pelivan, K., Frensemeier, L., Karst, U., Koellensperger, G., Bielec, B., Hager, S., Heffeter, P., Keppler, B. K. & Kowol, C. R.
The Analyst (2017) 142, 17, 3165-3176

Multifunctional alpha(v)beta(6) Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting
Conibear, A. C., Hager, S., Mayr, J., Klose, M. H. M., Keppler, B. K., Kowol, C. R., Heffeter, P. & Becker, C. F. W.
Bioconjugate Chemistry (2017) 28, 9, 2429-2439

DNA or protein? Capillary zone electrophoresismass spectrometry rapidly elucidates metallodrug binding selectivity
Artner, C., Holtkamp, H. U., Kandioller, W., Hartinger, C. G., Meier, S. M. & Keppler, B. K. 2
Chemical Communications (2017) 53, 57, 8002-8005

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin
Meier, S. M., Kreutz, D., Winter, L., Klose, M. H. M., Cseh, K., Weiss, T., Bileck, A., Alte, B., Mader, J. C., Jana, S., Chatterjee, A., Bhattacharyya, A., Hejl, M., Jakupec, M. A., Heffeter, P., Berger, W., Hartinger, C. G., Keppler, B. K., Wiche, G. & Gerner, C.
Angewandte Chemie (International Edition) (2017) 56, 28, 8267-8271

EGFR-targeting peptide-coupled platinum(IV) complexes
Mayr, J., Hager, S., Koblmueller, B., Klose, M. H. M., Holste, K., Fischer, B., Pelivan, K., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K.
Journal of Biological Inorganic Chemistry (2017) 22, 4, 591-603

Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition
Kubista, B., Schoefl, T., Mayr, L., van Schoonhoven, S., Heffeter, P., Windhager, R., Keppler, B. K. & Berger, W.
Journal of Experimental and Clinical Cancer Research (2017) 36, 52

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo
Mayr, J., Heffeter, P., Groza, D., Galvez, L., Koellensperger, G., Roller, A., Alte, B., Haider, M., Berger, W., Kowol, C. R. & Keppler, B. K.
Chemical Science (2017) 8, 3, 2241-2250

Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance
Englinger, B., Mair, M., Miklos, W., Pirker, C., Mohr, T., van Schoonhoven, S., Loetsch, D., Körner, W., Ferk, F., Knasmueller, S., Heffeter, P., Keppler, B. K., Grusch, M. & Berger, W.
British Journal of Cancer (2017) 116, 4, 489-500

Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse
Blazevic, A., Hummer, A. A., Heffeter, P., Berger, W., Filipits, M., Cibin, G., Keppler, B. K. & Rompel, A.
Scientific Reports (2017) 7, 40966

Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates
Riedl, C. A., Flocke, L. S., Hejl, M., Roller, A., Klose, M. H. M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Inorganic Chemistry (2017) 56, 1, 528-541

Comparative studies of oxaliplatin-based platinum(IV) complexes in different in vitro and in vivo tumor models
Goeschl, S., Schreiber-Brynzak, E., Pichler, V., Cseh, K., Heffeter, P., Jungwirth, U., Jakupec, M. A., Berger, W. & Keppler, B. K.
Metallomics (2017) 9, 3, 309-322

Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established
Kreutz, D., Bileck, A., Plessl, K., Wolrab, D., Groessl, M., Keppler, B. K., Meier, S. M. & Gerner, C.
Chemistry: A European Journal (2017) 23, 8, S. 1881-1890

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells
Domarco, O., Loetsch, D., Schreiber, J., Dinhof, C., Van Schoonhoven, S., Garcia, M. D., Peinador, C., Keppler, B. K., Berger, W. & Terenzi, A.
Dalton Transactions (Print Edition) (2017) 46, 2, 329-332

Fast High-Resolution Laser Ablation-Inductively Coupled Plasma Mass Spectrometry Imaging of the Distribution of Platinum-Based Anticancer Compounds in Multicellular Tumor Spheroids
Theiner, S., Van Malderen, S. J. M., Van Acker, T., Legin, A., Keppler, B. K., Vanhaecke, F. & Koellensperger
Analytical Chemistry (2017) 89, 23, 12641-12645

Comparative equilibrium and structural studies of new pentamethylcyclopentadienyl rhodium complexes bearing (O, N) donor bidentate ligands
Domotor, O., Hackl, C. M., Bali, K., Roller, A., Hejl, M., Jakupec, M. A., Keppler, B. K., Kandioller, W. & Enyedy, E. A.
Journal of Organometallic Chemistry (2017) 846, 287-295

Platinum(IV) Complexes Featuring Axial Michael Acceptor Ligands - Synthesis, Characterization, and Cytotoxicity
Sommerfeld, N. S., Strohhofer, D., Cseh, K., Theiner, S., Jakupec, M. A., Koellensperger, G., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2017) 34, 4049-4054

Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes
Hoefer, D., Varbanov, H. P., Hejl, M., Jakupec, M. A., Roller, A., Galanski, M. & Keppler, B. K.
Journal of Inorganic Biochemistry (2017) 174, 119-129

The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study
Heilos, D., Rodríguez-Carrasco, Y., Englinger, B., Timelthaler, G., van Schoonhoven, S., Sulyok, M., Boecker, S., Süssmuth, R. D., Heffeter, P., Lemmens-Gruber, R., Dornetshuber-Fleiss, R. & Berger, W. Toxins (2017) 9, 9

Low-Generation Polyamidoamine Dendrimers as Drug Carriers for Platinum(IV) Complexes
Sommerfeld, N. S., Hejl, M., Klose, M. H. M., Schreiber-Brynzak, E., Bileck, A., Meier, S. M., Gerner, C., Jakupec, M. A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2017) 12, 1713-1720

Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research
Lee, R. F. S., Theiner, S., Meibom, A., Koellensperger, G., Keppler, B. K. & Dyson, P. J.
Metallomics (2017) 9, 4, 365-381

Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents
Streciwilk, W., Terenzi, A., Misgeld, R., Frias, C., Jones, P. G., Prokop, A., Keppler, B. K. & Ott, I.
ChemMedChem (2017) 12, 3, 214-225

{Ru(CO)(x)}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo
Tamasi, G., Merlino, A., Scaletti, F., Heffeter, P., Legin, A. A., Jakupec, M. A., Berger, W., Messori, L., Keppler, B. K. & Cini, R.
Dalton Transactions (Print Edition) (2017) 46, 9, 3025-3040

Synthesis, Characterization, and Time-Dependent NMR Spectroscopy Studies of (SP-4-2)-[(trans-1R,2R/1S,2S-N-15(2))-Cyclohexane-1,2-diamine][(C-13(2))oxalato]platinum(II)
Hoefer, D., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2017) 17, 2347-2354

Functionalization of Ruthenium(II)(eta(6)-p-cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies
Hanif, M., Meier, S. M., Adhireksan, Z., Henke, H., Martic, S., Movassaghi, S., Labib, M., Kandioller, W., Jamieson, S. M. F., Hejl, M., Jakupec, M. A., Kraatz, H-B., Davey, C. A., Keppler, B. K. & Hartinger, C. G.
Chempluschem (2017) 82, 6, 841-847

Antiproliferative Copper(II) and Platinum(II) Complexes with Bidentate N,N-Donor Ligands
Sommerfeld, N. S., Guelzow, J., Roller, A., Cseh, K., Jakupec, M. A., Grohmann, A., Galanski, M. & Keppler, B. K.
European Journal of Inorganic Chemistry (2017) 24, 3115-3124

Amidoxime platinum(II) complexes: pH-dependent highly selective generation and cytotoxic activity
Bolotin, D. S., Demakova, M. Y., Legin, A. A., Suslonov, V. V., Nazarov, A. A., Jakupec, M. A., Keppler, B. K. & Kukushkin, V. Y.
New Journal of Chemistry (2017) 41, 14, 6840-6848

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue
Klose, M. H. M., Hejl, M., Heffeter, P., Jakupec, M. A., Meier, S. M., Berger, W. & Keppler, B. K.
The Analyst (2017) 142, 13, 2327-2332

Characterizing activation mechanisms and binding preferences of ruthenium metallo-prodrugs by a competitive binding assay
Artner, C., Holtkamp, H. U., Hartinger, C. G. & Meier-Menches, S. M.
Journal of Inorganic Biochemistry (2017) 177, 322-327

2016

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
Miklos, W., Heffeter, P., Pirker, C., Hager, S., Kowol, C. R., van Schoonhoven, S., Stojanovic, M., Keppler, B. K. & Berger, W.
Onco Target (2016) 7, 51, 84556-84574

DNA-Binding and Anticancer Activity of Pyrene-Imidazolium Derivatives
Bonsignore, R., Notaro, A., Salvo, A. M. P., Spinello, A., Fiasconaro, G., Terenzi, A., Giacalone, F., Keppler, B., Giuliano, M., Gruttadauria, M. & Barone, G.
Chemistry SELECT (2016) 1, 21, 6755–6761

Anticancer metal drugs and immunogenic cell death
Terenzi, A., Pirker, C., Keppler, B. K. & Berger, W.
Journal of Inorganic Biochemistry (2016) 165, 71-79

Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior
Hackl, C. M., Legina, M. S., Pichler, V., Schmidlehner, M., Roller, A., Domotor, O., Enyedy, E. A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Chemistry: A European Journal (2016) 22, 48, 17269-17281

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs
Karnthaler-Benbakka, C., Groza, D., Koblmueller, B., Terenzi, A., Holste, K., Haider, M., Baier, D., Berger, W., Heffeter, P., Kowol, C. R. & Keppler, B. K.
ChemMedChem (2016) 11, 21, 2410-2421

Towards targeting anticancer drugs: ruthenium(II)-arene complexes with biologically active naphthoquinone-derived ligand systems
Kubanik, M., Kandioller, W., Kim, K., Anderson, R. F., Klapproth, E., Jakupec, M. A., Roller, A., Sohnel, T., Keppler, B. K. & Hartinger, C. G.
Dalton Transactions (Print Edition) (2016) 45, 33, 13091-13103

G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes
Bonsignore, R., Terenzi, A., Spinello, A., Martorana, A., Lauria, A., Almerico, A. M., Keppler, B. K. & Barone, G.
Journal of Inorganic Biochemistry (2016) 161, 115-121

Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes
Henke, H., Kryeziu, K., Banfic, J., Theiner, S., Körner, W., Brueggemann, O., Berger, W., Keppler, B., Heffeter, P. & Teasdale, I.
Macromolecular Bioscience (2016) 16, 8, 1239-1249

Impact of Stepwise NH2-Methylation of Triapine on the Physicochemical Properties, Anticancer Activity, and Resistance Circumvention
Kowol, C. R., Miklos, W., Pfaff, S., Hager, S., Kallus, S., Pelivan, K., Kubanik, M., Enyedy, E. A., Berger, W., Heffeter, P. & Keppler, B. K.
Journal of Medicinal Chemistry (2016) 59, 14, 6739-6752

Biodistribution of the novel anticancer drug sodium trans-Retrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action
Bytzek, A. K., Koellensperger, G., Keppler, B. K. & Hartinger, C. G.
Journal of Inorganic Biochemistry (2016) 160, 250-255

Differences in protein binding and excretion of Triapine and its Fe(III) complex
Pelivan, K., Miklos, W., Van Schoonhoven, S., Köllensperger, G., Gille, L., Berger, W., Heffeter, P., Kowol, C. & Keppler, B.
Journal of Inorganic Biochemistry (2016) 160, 61-69

The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs
Göschl, S., Varbanov, H., Theiner, S., Jakupec, M., Galanski, M. & Keppler, B.
Journal of Inorganic Biochemistry (2016) 160, 264-274

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism
Bijelic, A., Theiner, S., Keppler, B. K. & Rompel, A.
Journal of Medicinal Chemistry (2016) 59, 12, 5894-5903

Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles
Novak, M. S., Buechel, G. E., Keppler, B. K. & Jakupec, M. A.
Journal of Biological Inorganic Chemistry (2016) 21, 3, 347-356

Molecular mode of action of NKP-1339-a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines
Flocke, L. S., Trondl, R., Jakupec, M. A. & Keppler, B. K.
Investigational New Drugs (2016) 34, 3, 261-268

Behavior of platinum(IV) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation
Schreiber-Brynzak, E., Pichler, V., Heffeter, P., Hanson, B., Theiner, S., Lichtscheidl-Schultz, I., Kornauth, C., Bamonti, L., Dhery, V., Groza, D., Berry, D., Berger, W., Galanski, M., Jakupec, M. A. & Keppler, B. K.
Metallomics (2016) 8, 4, 422-433

Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy
Wilfinger, N., Austin, S., Scheiber-Mojdekhar, B., Berger, W., Reipert, S., Praschberger, M., Paur, J., Trondl, R., Keppler, B. K., Zielinski, C. C. & Nowikovsky, K.
Onco Target (2016) 7, 2, 1242-1261

Another step toward DNA selective targeting: Ni-II and Cu-II complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes
Terenzi, A., Loetsch, D., van Schoonhoven, S., Roller, A., Kowol, C. R., Berger, W., Keppler, B. K. & Barone, G.
Dalton Transactions (Print Edition) (2016) 45, 18, 7758-7767     

Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics
Schmidlehner, M., Flocke, L. S., Roller, A., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (Print Edition) (2016) 45, 2, 724-733     

LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs
Theiner, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M., Koellensperger, G. & Keppler, B. K.
Metallomics (2016) 8, 4, 398-402

Multi-scale imaging of anticancer platinum(IV) compounds in murine tumor and kidney
Legin, A. A., Theiner, S., Schintlmeister, A., Reipert, S., Heffeter, P., Jakupec, M. A., Mayr, J., Varbanov, H. P., Kowol, C. R., Galanski, M., Berger, W., Wagner, M. & Keppler, B. K.
Chemical Science (2016) 7, 5, 3052-3061

Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity
Fischer, B., Kryeziu, K., Kallus, S., Heffeter, P., Berger, W., Kowol, C. R. & Keppler, B. K.
RSC Advances (2016) 6, 61, 55848-55859    

DNA-Binding and Anticancer Activity of Pyrene-Imidazolium Derivatives
Bonsignore, R., Notaro, A., Salvo, A. M. P., Spinello, A., Fiasconaro, G., Terenzi, A., Giacalone, F., Keppler, B., Giuliano, M., Gruttadauria, M. & Barone, G.
Chemistry SELECT (2016) 1, 21, 6755–6761

Flavonoid-Based Organometallics with Different Metal Centers - Investigations of the Effects on Reactivity and Cytotoxicity
Kurzwernhart, A., Mokesch, S., Klapproth, E., Adib Razavi, M. S., Jakupec, M. A., Hartinger, C. G., Kandioller, W. & Keppler, B. K.
European Journal of Inorganic Chemistry (2016) 2, 240-246

2015

Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy
Höfer, D., Varbanov, H. P., Legin, A., Jakupec, M. A., Roller, A., Galanski, M. & Keppler, B. K.
Journal of Inorganic Biochemistry (2015) 153, 259-271

Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2 '-bipyridine and ethylenediamine and their interaction with human serum albumin
Enyedy, E. A., Meszaros, J. P., Doemoetoer, O., Hackl, C. M., Roller, A., Keppler, B. K. & Kandioller, W.
Journal of Inorganic Biochemistry (2015) 152, 93-103

Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity
Kowol, C. R., Nagy, N. V., Jakusch, T., Roller, A., Heffeter, P., Keppler, B. K. & Enyedy, E. A.
Journal of Inorganic Biochemistry (2015) 152, 62-73

Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs
Schreiber-Brynzak, E., Klapproth, E., Unger, C., Lichtscheidl-Schultz, I., Goeschl, S., Schweighofer, S., Trondl, R., Dolznig, H., Jakupec, M. A. & Keppler, B. K.
Investigational New Drugs (2015) 33, 4, 835-847

Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex
Habala, L., Bartel, C., Giester, G., Jakupec, M. A., Keppler, B. K. & Rompel, A.
Journal of Inorganic Biochemistry (2015) 147, 147-152

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance
Miklos, W., Pelivan, K., Kowol, C. R., Pirker, C., Dornetshuber-Fleiss, R., Spitzwieser, M., Englinger, B., van Schoonhoven, S., Cichna-Markl, M., Koellensperger, G., Keppler, B. K., Berger, W. & Heffeter, P.
Cancer Letters (2015) 361, 1, 112-120

Bis- and Tetrakis(carboxylato)platinum(IV) Complexes with Mixed Axial Ligands - Synthesis, Characterization, and Cytotoxicity
Hoffmeister, B. R., Hejl, M., Adib-Razavi, M. S., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Chemistry & Biodiversity (2015) 12, 4, 559-574

Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application
Theiner, S., Varbanov, H. P., Galanski, M., Egger, A. E., Berger, W., Heffeter, P. & Keppler, B. K. Jan
Journal of Biological Inorganic Chemistry (2015) 20, 1, 89-99

Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential
Kuhn, P. -S., Pichler, V., Roller, A., Hejl, M., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Dalton Transactions (Print Edition) (2015) 44, 2, 659-668

Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G(2)/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines
Pichler, V., Goeschl, S., Schreiber-Brynzak, E., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Metallomics (2015) 7, 7, 1078-1090

Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents
Theiner, S., Kornauth, C., Varbanov, H. P., Galanski, M., Van Schoonhoven, S., Heffeter, P., Berger, W., Egger, A. E. & Keppler, B. K.
Metallomics: (2015) 7, 8, 1256-1264

The rearrangement of tosylated flavones to 1 '-(alkylamino)aurones with primary amines
Kandioller, W., Kubanik, M., Bytzek, A. K., Jakupec, M. A., Roller, A., Keppler, B. K. & Hartinger, C. G.
Tetrahedron (2015) 71, 47, 8953-8959

Organometallic complexes of (thio)allomaltol-based Mannich-products: Synthesis, stability and preliminary biological investigations
Schmidlehner, M., Pichler, V., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Journal of Organometallic Chemistry (2015) 782, 69-76

Bis- and Tris(carboxylato)platinum(IV) Complexes with Mixed Am(m)ine Ligands in the trans Position Exhibiting Exceptionally High Cytotoxicity
Hoffmeister, B. R., Hejl, M., Jakupec, M. A., Galanski, M. & Keppler, B. K. Apr 2015 in : European Journal of Inorganic Chemistry (2015) 10, 1700-1708

Half-Sandwich Ruthenium(II) Biotin Conjugates as Biological Vectors to Cancer Cells
Babak, M. V., Plazuk, D., Meier, S. M., Arabshahi, H. J., Reynisson, J., Rychlik, B., Blauz, A., Szulc, K., Hanif, M., Strobl, S., Roller, A., Keppler, B. K. & Hartinger, C. G.
Chemistry: A European Journal (2015) 21, 13, 5110-5117

1,3-Dioxoindan-2-carboxamides as Bioactive Ligand Scaffolds for the Development of Novel Organometallic Anticancer Drugs
Mokesch, S., Novak, M. S., Roller, A., Jakupec, M. A., Kandioller, W. & Keppler, B. K.
Organometallics (2015) 34, 5, 848-857

2014

Tumor-Targeting of EGFR Inhibitors by Hypoxia-Mediated Activation
Karnthaler-Benbakka, C., Groza, D., Kryeziu, K., Pichler, V., Roller, A., Berger, W., Heffeter, P. & Kowol, C. R.
Angewandte Chemie (International Edition) (2014) 53, 47, 12930-12935

Calpain-mediated integrin deregulation as novel mode of action for the anticancer gallium compound KP46. Molecular Cancer Therapeutics
Jungwirth, U., Gojo, J., Tuder, T., Walko, G., Holcmann, M., Schoefl, T., Nowikovsky, K., Wilfinger, N., Schoonhoven, S., Kowol, C. R., Lemmens, R., Heffeter, P., Keppler, B. K. & Berger, W.
Molecular Cancer Therapeutics (2014) 13, 10, 2436-2449

A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs
Varbanov, H. P., Goeschl, S., Heffeter, P., Theiner, S., Roller, A., Jensen, F., Jakupec, M. A., Berger, W., Galanski, M. & Keppler, B. K.
Journal of Medicinal Chemistry (2014) 57, 15, 6751-6764

Enhanced Anticancer Activity and Circumvention of Resistance Mechanisms by Novel Polymeric/Phospholipidic Nanocarriers of Doxorubicin
Senkiv, Y., Riabtseva, A., Heffeter, P., Boiko, N., Kowol, C. R., Jungwith, U., Shlyakhtina, Y., Garasevych, S. G., Mitina, N., Berger, W., Zaichenko, A. & Stoika, R.
Journal of Biomedical Nanotechnology. 10, 7, S. 1369-1381 13 S.

Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: Synthesis, solution speciation and bioactivity
Doemoetoer, O., Aicher, S., Schmidlehner, M., Novak, M. S., Roller, A., Jakupec, M. A., Kandioller, W., Hartinger, C. G., Keppler, B. K. & Enyedy, E. A.
Journal of Inorganic Biochemistry (2014) 134, 57-65

Nanoformulation Improves Activity of the (pre)Clinical Anticancer Ruthenium Complex KP1019
Heffeter, P., Riabtseva, A., Senkiv, Y., Kowol, C. R., Koerner, W., Jungwith, U., Mitina, N., Keppler, B. K., Konstantinova, T., Yanchuk, I., Stoika, R., Zaichenko, A. & Berger, W.
Journal of Biomedical Nanotechnology (2014) 10, 5, 877-884

Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions*
Legin, A. A., Jakupec, M. A., Bokach, N. A., Tyan, M. R., Kukushkin, V. Y. & Keppler, B. K.
Journal of Inorganic Biochemistry (2014) 133, 33-39

Triapine and a More Potent Dimethyl Derivative Induce Endoplasmic Reticulum Stress in Cancer Cells
Trondl, R., Flocke, L. S., Kowol, C. R., Heffeter, P., Jungwirth, U., Mair, G. E., Steinborn, R., Enyedy, E. A., Jakupec, M. A., Berger, W. & Keppler, B. K.
Molecular Pharmacology (2014) 85, 3, 451-459

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
Trondl, R., Heffeter, P., Kowol, C. R., Jakupec, M. A., Berger, W. & Keppler, B. K.
Chemical Science (2014) 5, 8, 2925-2932

Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation
Fischer, B., Heffeter, P., Kryeziu, K., Gille, L., Meier, S. M., Berger, W., Kowol, C. R. & Keppler, B. K.
Dalton Transactions (Print Edition) (2014) 43, 3, 1096-1104

Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice
Egger, A. E., Theiner, S., Kornauth, C., Heffeter, P., Berger, W., Keppler, B. K. & Hartinger, C.
Metallomics (2014) 6, 9, 1616-1625

Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers
Meier, S. M., Babak, M. V., Keppler, B. K. & Hartinger, C. G.
ChemMedChem (2014) 9, 7, 1351-1355

Efficiently Detecting Metallodrug-Protein Adducts: Ion Trap versus Time-of-Flight Mass Analyzers
Meier, S. M., Babak, M. V., Keppler, B. K. & Hartinger, C. G.
ChemMedChem (2014) 9, 7, 1351-1355

2013

Solution equilibria of anticancer ruthenium(II)-(eta(6)-p-cymene)-hydroxy(thio)pyr(id) one complexes: Impact of sulfur vs. oxygen donor systems on the speciation and bioactivity
Enyedy, E. A., Sija, E., Jakusch, T., Hartinger, C. G., Kandioller, W., Keppler, B. K. & Kiss, T.
Journal of Inorganic Biochemistry (2013) 127, 161-168

The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo
Heffeter, P., Atil, B., Kryeziu, K., Groza, D., Koellensperger, G., Koerner, W., Jungwirth, U., Mohr, T., Keppler, B. K. & Berger, W.
European Journal of Cancer (2013) 49, 15,  3366-3375

A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2 '-deoxyguanosine 5'-monophosphate (dGMP)
Grabmann, G., Keppler, B. K. & Hartinger, C. G.
Analytical and Bioanalytical Chemistry (2013) 405, 20, 6417-6424

Bulky N(,N)-(Di)alkylethane-1,2-diamineplatinum(II) Compounds as Precursors for Generating Unsymmetrically Substituted Platinum(IV) Complexes
Pichler, V., Goeschl, S., Meier, S. M., Roller, A., Jakupec, M. A., Galanski, M. & Keppler, B. K.
Inorganic Chemistry (2013) 52, 14, 8151-8162

Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate
Meier, S. M., Novak, M., Kandioller, W., Jakupec, M. A., Arion, V. B., Metzler-Nolte, N., Keppler, B. K. & Hartinger, C. G.
Chemistry: A European Journal (2013) 19, 28, 9297-9307

Am(m)ines Make the Difference: Organoruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development
Babak, M., Meier, S. M., Legin, A., Adib Razavi, M. S., Roller, A., Jakupec, M., Keppler, B. & Hartinger, C. G.
Chemistry: A European Journal (2013) 19, 13, 4308-4318

Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes
Valiahdi, S. M., Egger, A., Miklos, W., Jungwirth, U., Meelich, K., Berger, W., Hartinger, C. G., Galanski, M., Jakupec, M. & Keppler, B.
Journal of Biological Inorganic Chemistry (2013) 18, 2, 249-260

Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery
Pichler, V., Mayr, J., Heffeter, P., Domotor, O., Enyedy, E. A., Hermann, G., Groza, D., Köllensperger, G., Galanski, M., Berger, W., Keppler, B. & Kowol, C.
Chemical Communications (2013) 49, 22, 2249-2251

Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
Filak, L., Göschl, S., Heffeter, P., Egger, A., Jakupec, M., Keppler, B., Berger, W. & Arion, V.
Organometallics (2013) 32, 3, 903-914

Novel metal(II) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents
Meier, S. M., Adhireksan, Z., Pichler, V., Novak, M., Jirkovsky, E., Jakupec, M., Arion, V., Davey, C. A., Keppler, B. & Hartinger, C.
Chemical Science (2013) 4, 4, 1837-1846

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
Kandioller, W., Balsano, E., Meier, S. M., Jungwirth, U., Göschl, S., Roller, A., Jakupec, M., Berger, W., Keppler, B. & Hartinger, C. G.
Chemical Communications (2013) 49, 32, 3348-3350

Synergistic Anticancer Activity of Arsenic Trioxide with Erlotinib Is Based on Inhibition of EGFR-Mediated DNA Double-Strand Break Repair
Kryeziu, K., Jungwirth, U., Hoda, M. A., Ferk, F., Karnthaler-Benbakka, C., Knasmüller, S., Kowol, C., Berger, W. & Heffeter, P.
Molecular Cancer Therapeutics (2013) 12, 6, 1073-1084

X-ray Absorption Near Edge Structure Spectroscopy to Resolve the in Vivo Chemistry of the Redox-Active Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019)
Hummer, A., Heffeter, P., Berger, W., Filipits, M., Batchelor, D., Büchel, G., Jakupec, M., Keppler, B. & Rompel, A.
Journal of Medicinal Chemistry (2013) 56, 3, 1182-1196

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru-II(arene) anticancer complexes with biologically active ligands
Kurzwernhart, A., Kandioller, W., Enyedy, E. A., Novak, M., Jakupec, M., Keppler, B. & Hartinger, C. G.
Dalton Transactions (Print Edition) (2013) 42, 17, 6193-6202

2012

A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines
Ginzinger, W., Mühlgassner, G., Arion, V., Jakupec, M., Roller, A., Galanski, M., Reithofer, M., Berger, W. & Keppler, B.
Journal of Medicinal Chemistry (2012) 55, 7, 3398-3413

Anticancer Activity of Methyl-Substituted Oxaliplatin Analogs
Jungwirth, U., Xanthos, D. N., Gojo, J., Bytzek, A., Körner, W., Heffeter, P., Abramkin, S., Jakupec, M., Hartinger, C., Windberger, U., Galanski, M., Keppler, B. & Berger, W.
Molecular Pharmacology (2012) 81, 5, 719-728

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
Mühlgassner, G., Bartel, C., Schmid, W., Jakupec, M., Arion, V. & Keppler, B.
Journal of Inorganic Biochemistry (2012) 116, 180-187

Biomolecule binding vs. anticancer activity: Reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins
Meier, S. M., Kandioller, W., Keppler, B. & Hartinger, C.
Journal of Inorganic Biochemistry (2012) 108, 91-95

Capillary zone electrophoresis and capillary zone electrophoresis-electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions
Grabmann, G., Meier, S. M., Scaffidi-Domianello, Y., Galanski, M., Keppler, B. & Hartinger, C. G.
Journal of Chromatography A (2012) 1267, SI, 156-161

Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds
Bartel, C., Bytzek, A., Scaffidi-Domianello, Y., Grabmann, G., Jakupec, M., Hartinger, C., Galanski, M. & Keppler, B.
Journal of Biological Inorganic Chemistry (2012) 17, 3, 465-474

Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands
Enyedy, E. A., Domotor, O., Varga, E., Kiss, L., Trondl, R., Hartinger, C. G. & Keppler, B.
Journal of Inorganic Biochemistry (2012) 117, 189-197

Diamminetetrakis(carboxylato)platinum(IV) Complexes - Synthesis, Characterization, and Cytotoxicity
Hoffmeister, B., Adib Razavi, M. S., Jakupec, M., Galanski, M. & Keppler, B.
Chemistry & Biodiversity (2012) 9, 9, SI, 1840-1848

Fragmentation methods on the balance: unambiguous top-down mass spectrometric characterization of oxaliplatin-ubiquitin binding sites
Meier, S. M., Tsybin, Y. O., Dyson, P. J., Keppler, B. & Hartinger, C.
Analytical and Bioanalytical Chemistry (2012) 402, 8, 2655-2662

Impact of terminal dimethylation on the resistance profile of alpha-N-heterocyclic thiosemicarbazones
Heffeter, P., Pirker, C., Kowol, C., Herrman, G., Dornetshuber-Fleiss, R., Miklos, W., Jungwirth, U., Köllensperger, G., Keppler, B. & Berger, W.
Biochemical Pharmacology (2012) 83, 12, 1623-1633

Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds
Kowol, C., Heffeter, P., Miklos, W., Gille, L., Trondl, R., Cappellacci, L., Berger, W. & Keppler, B.
Journal of Biological Inorganic Chemistry (2012) 17, 3, 409-423

Novel Oximato-Bridged Platinum(II) Di- and Trimer(s): Synthetic, Structural, and in Vitro Anticancer Activity Studies
Scaffidi-Domianello, Y., Legin, A., Jakupec, M., Roller, A., Kukushkin, V. Y., Galanski, M. & Keppler, B.
Inorganic Chemistry (2012) 51, 13, 7153-7163

Organometallic Ruthenium and Osmium Compounds of Pyridin-2-and-4-ones as Potential Anticancer Agents
Kandioller, W., Hanif, M., Keppler, B. & Hartinger, C. G.
Chemistry & Biodiversity (2012) 9, 9, SI, 1718-1727

Osmium(IV) complexes with 1H- and 2H-indazoles: Tautomer identity versus spectroscopic properties and antiproliferative activity
Büchel, G., Stepanenko, I., Hejl, M., Jakupec, M., Keppler, B., Heffeter, P., Berger, W. & Arion, V.
Journal of Inorganic Biochemistry (2012) 113, 47-54

Structure-Activity Relationships of Targeted Ru-II(eta(6)-p-Cymene) Anticancer Complexes with Flavonol-Derived Ligands
Kurzwernhart, A., Kandioller, W., Bächler, S., Bartel, C., Martic, S., Buczkowska, M., Mühlgassner, G., Jakupec, M., Kraatz, H-B., Bednarski, P. J., Arion, V., Marko, D., Keppler, B. & Hartinger, C. G.
Journal of Medicinal Chemistry (2012) 55, 23, 10512-10522

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder
Kurzwernhart, A., Kandioller, W., Bartel, C., Bächler, S., Trondl, R., Mühlgassner, G., Jakupec, M., Arion, V., Marko, D., Keppler, B. & Hartinger, C.
Chemical Communications (2012) 48, 40, 4839-4841

Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: Synthesis, characterization, and biological activity
Pichler, V., Heffeter, P., Valiahdi, S. M., Kowol, C., Egger, A., Berger, W., Jakupec, M., Galanski, M. & Keppler, B
Journal of Medicinal Chemistry (2012) 55, 24, 11052-11061

Water-Soluble Cationic Derivatives of Indirubin, the Active Anticancer Component from Indigo naturalis
Ginzinger, W., Egger, A., Mühlgassner, G., Arion, V., Jakupec, M., Galanski, M., Berger, W. & Keppler, B.
Chemistry & Biodiversity (2012) 9, 10, 2175-2185

2011

From hydrolytically labile to hydrolytically stable Ru-II-arene anticancer complexes with carbohydrate-derived co-ligands
Hanif, M., Meier, S. M., Kandioller, W., Bytzek, A., Hejl, M., Hartinger, C. G., Nazarov, A. A., Arion, V. B., Jakupec, M. A., Dyson, P. J. & Keppler, B. K.
Journal of Inorganic Biochemistry (2011) 105, 2, 224-231

Anticancer Activity of Metal Complexes: Involvement of Redox Processes
Jungwirth, U., Kowol, C., Keppler, B., Hartinger, C. Berger, W., & Heffeter, P.
Antioxidants and Redox Signaling (2011) 15, 4, 1085-1127

Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019
Bartel, C., Jakupec, M., Heffeter, P., Galanski, M., Berger, W. & Keppler, B.
Journal of Biological Inorganic Chemistry (2011) 16, 8, 1205-1215

LC- and CZE-ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma
Bytzek, A., Böck, K., Hermann, G., Hann, S., Keppler, B., Hartinger, C. & Köllensperger, G.
Metallomics (2011) 3, 10, 1049-1055

Mono-carboxylated diaminedichloridoplatinum(IV) complexes - selective synthesis, characterization, and cytotoxicity
Pichler, V., Valiahdi, S. M., Jakupec, M., Arion, V., Galanski, M. & Keppler, B.
Dalton Transactions (Print Edition) (2011) 40, 32, 8187-8192

Pyrone derivatives and metals: From natural products to metal-based drugs
Kandioller, W., Kurzwernhart, A., Meier, S. M., Keppler, B. & Hartinger, C.
Journal of Organometallic Chemistry (2011) 696, 5, 999-1010

Synthesis, Characterization, and Cytotoxic Activity of Novel Potentially pH-Sensitive Nonclassical Platinum(II) Complexes Featuring 1,3-Dihydroxyacetone Oxime Ligands
Scaffidi-Domianello, Y., Legin, A., Jakupec, M., Arion, V., Kukushkin, V. Y., Galanski, M. & Keppler, B.
Inorganic Chemistry (2011) 50, 21, 10673-10681

Fibroblast Growth Factor Receptors as Therapeutic Targets in Human Melanoma: Synergism with BRAF Inhibition
Metzner, T.; Bedeir, A.; Held, G.; Peter-Vörösmarty, B.; Ghassemi, S.; Heinzle, C.; Spiegl-Kreinecker, S.; Marian, B.; Holzmann, K.; Grasl-Kraupp, B.; Pirker, C.; Micksche, M.; Berger, W.; Heffeter, P.; Grusch, M.
Journal of Investigative Dermatology (2011) 131, 2087-2095

2010

Is the Reactivity of M(II)-Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter?
Hanif, M., Henke, H., Meier, S. M., Martic, S., Labib, M., Kandioller, W., Jakupec, M. A., Arion, V. B., Kraatz, H-B., Keppler, B. K. & Hartinger, C. G.
Inorganic Chemistry (2010) 49, 17, 7953-7963

Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)-(eta(6)-Arene) Complexes
Kandioller, W., Hejl, M., Jakupec, M., Roller, A., Keppler, B. & Hartinger, C.
Australian Journal of Chemistry (2010) 63, 11, 1521-1528

Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339
Heffeter, P., Böck, K., Atil, B., Reza Hoda, M. A., Körner, W., Bartel, C., Jungwirth, U., Keppler, B., Micksche, M., Berger, W. & Köllensperger, G.
Journal of Biological Inorganic Chemistry (2010) 15, 5, 737-748

Novel cis- and trans-configured bis(oxime)platinum(II) complexes: Synthesis, characterization, and cytotoxic activity
Scaffidi-Domianello, Y., Meelich, K., Jakupec, M., Arion, V., Kukushkin, V. Y., Galanski, M. & Keppler, B.
Inorganic Chemistry (2010) 49, 12, 5669-5678

Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy
Filak, L., Mühlgassner, G., Jakupec, M., Heffeter, P., Berger, W., Arion, V. & Keppler, B.
Journal of Biological Inorganic Chemistry (2010) 15, 6, 903-918

Osmium(II)- versus ruthenium(II)-arene carbohydrate-based anticancer compounds: similarities and differences
Nazarov, A., Hartinger, C., Kandioller, W., Jakupec, M., Arion, V., Dyson, P. J. & Keppler, B. 2010 in : Dalton Transactions (Print Edition) (2010) 39, 31, 7345-7352

{(1R,2R,4R)-4-Methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): A Novel Enantiomerically Pure Oxaliplatin Derivative Showing Improved Anticancer Activity in Vivo
Abramkin, S., Jungwirth, U., Valiahdi, S. M., Dworak, C., Habala, L., Meelich, K., Berger, W., Jakupec, M., Hartinger, C., Nazarov, A. A., Galanski, M. & Keppler, B.
Journal of Medicinal Chemistry (2010) 53, 20, 7356-7364 

2009

Impact of metal coordination on cytotoxicity of 3-aminopyridine-2- carboxaldehyde thiosemicarbazone (Triapine) and novel insights into terminal dimethylation
Kowol, C., Trondl, R., Heffeter, P., Arion, V., Jakupec, M., Roller, A., Galanski, M., Berger, W. & Keppler, B.  Journal of Medicinal Chemistry (2009) 52, 16, 5032-5043